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Researchers now have the capability to profile entire microbial communities and discover the underlying dynamic specificity of the each changing environment. Microbiologists have utilized the plexWell™ technology for its intrinsic normalization and increased library prep throughput, but plexWell™ has additionally shown to tolerate a wide range of GC-content samples with the ability to multiplex those multiple GC sample types in the same library prep without sacrificing performance.