In order to adopt such a scaled-up effort to track the emergence and divergence of SARS-CoV-2 in New York state, we had to identify the best enrichment PCR protocol, and so we did a lot of searching. We looked and found the ARTIC v3 protocol using the ExpressPlex method and that seemed highly attractive to us because of the scalability. It actually enabled us to implement low, moderate, and even higher throughput as needed. It wouldn’t have been possible to do without the one-step ExpressPlex workflow.