Scalable Low-Pass Sequencing for Humans, Plants & Animals
Scalable prep. Population-scale data. Genome-wide Insights
seqWell library prep solutions have you covered – human, plant & animal.
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Population-level insights
Identify rare variants
Detect structural variants & copy number variants
GENOtyping at scale
Enable broad screening
Capture diversity
Imputation for high-depth information at a fraction of the cost
Confidence
Larger data sets for increased statistical power
Better genotype-to-phenotype linkage
Genome-wide information
SHORT-READ & LONG-READ Low-Pass Sequencing Solutions
Unlike the inflexibility of microarrays, affordable low pass sequencing or SKIM-seq turn genomics into a powerful avenue of discovery AND a predictive, decision-making tool when used at scale. seqWell library prep solutions are the engine behind scalable low-pass, short- & long-read sequencing to cost-effectively generate population-scale, genome-wide insights.
AgriPrep Library Prep Kit – propelling population-scale, low-pass WGS and SKIM-seq applications for plants, animals & humans using an affordable, one-step library prep workflow for scalable NGS
LongPlex Multiplexing Kit – combining high-throughput fragmentation & multiplexing with long-read low-pass sequencing to unlock discovery and genotyping of simple and complex variants
MosaiX – scalable library prep with flexible indexing based on seqWell directional tagmentation that generates high-performance libraries for hybrid capture studies or WGS
Low-Pass WGS as an Alternative to Microarrays
While microarray-based platforms have historically been used for genotyping, Genotyping-by-Sequencing (GBS) approaches, particularly low-pass, whole-genome sequencing (lpWGS), have emerged as cost-effective alternatives that capture genome-wide variation with high accuracy. By sequencing samples at low coverage and leveraging dense reference panels, lpWGS enables robust genotype inference across millions of variants.
AgriPrep library prep made conversion of microarray-based mouse genotyping to lpWGS a reality for the JAX Genome Technologies Laboratory at The Jackson Laboratory.
POSTER: Single-Step Library Preparation Workflow Enables High-Throughput Low-Pass Whole-Genome Sequencing Without Compromising Accuracy
Customer Posters
MosaiX 
AgriPrep – Center for Aquaculture Technologies
High Throughput Low Pass Whole Genome Sequencing for Genomics Applications in Aquaculture
LongPlex – HudsonAlpha Institute for Biotechnology
Long-Read Low-Pass Sequencing: A Scalable Strategy for High-Resolution Genotyping
Blogs of Interest
Beyond Arrays: How a Blended Low Pass + Targeted GBS Strategy Is Reshaping AgBio Genotyping
