NGS Workflows for Expedited Development & Manufacturing of Therapeutic Antibodies

In this webinar, scientists from Moderna and seqWell will present several applications of a fully scalable, streamlined NGS library preparation workflow that span antibody development and biomanufacturing.

Moderna presentation – Antibody Sequencing: New Operating Model

seqWell presentation – Ultra High Throughput NGS Workflows for Plasmid QC aned Biological Discovery

In the first presentation, Nasthas Lacerda Almeida, a research associate, from Next Generation Analytics (NGA) at Moderna, will present an optimized clonal antibody sequencing approach, optimized for speed and scalability, using an automated, highly multiplexed library preparation method.  In the second presentation, Joe Mellor, PhD, co-founder & CSO, seqWell, will show data highlighting how this same streamlined library prep workflow can be harnessed for early-stage synthetic construct screening as well as an application used to address clonality concerns due to bacteria co-transformation.

During the webinar, you’ll learn:

• How Moderna performs high-throughput, accurate clonal antibody sequencing using de novo assembly of NGS short reads
• How to use NGS to identify impurities caused by plasmid co-transformation in biologics discovery pipelines
• How rapid, massively multiplexed NGS library prep can eliminate bottlenecks in ultra-high-throughput synthetic construct screening
• How a single, automated, one-step library preparation workflow supports early- and late-stage NGS needs resulting in cost and labor savings, increases throughput and workflow speed, and enhances the overall quality of results